Management and Treatment How do I treat hiccups? Because the exact cause of hiccups is uncertain, some remedies may or may not work. These home treatments will not hurt you, so there is typically no harm in trying them. Home treatments include: Drinking water quickly. Nov 18, · Baclofen is an effective treatment for hiccups because it relaxes your muscles. Keeping your muscles relaxed helps calm your body and settle your diaphragm, stopping your hiccups once and .